Chin Ken Wong,a,b,c Fan Chen,a,c Alexander F. Mason,a,b Martina H. Stenzel,a,c* Pall Thordarson,a,b*

 

aSchool of Chemistry, University of New South Wales, Sydney, NSW 2052, Australia.
b
The Australian Centre for Nanomedicine and the ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, University of New South Wales, Sydney, NSW 2052, Australia.
cCentre for Advanced Macromolecular Design (CAMD), University of New South Wales, Sydney, NSW 2052, Australia.

 

Recently, we developed a supramolecular strategy that allows us to prepare intrinsically fluorescent polymersomes with various shapes (spheres, ellipsoids and tubes) and sizes, using only one polymer of the same block length/composition (and of the same amount, mass-wise).

In this presentation, we will demonstrate the potential use of some of these polymersomes as bioimaging/drug delivery vehicles, and show how changes in polymersome shape and size influence their cellular uptake properties and tumour penetration ability. Towards the end of this presentation, we will demonstrate the robustness of our shape transformation method, and how it can extended to prepare more complex, polyhedral-shaped polymersomes that resemble viral capsids (protein shell of viruses).