Antibody conjugated carbon quantum dots for targeted delivery of metronidazole into Porphyromonas gingivalis

Sara Madadi Ardekani, Alireza Dehghani, Vincent G. Gomes*, Ky-Anh Nguyen, Mahbub Hassan

The University of Sydney, School of Chemical & Biomolecular Engineering, NSW 2006, Australia
*Corresponding author: vincent.gomes@sydney.edu.au; Fax: +61293512854; Tel: +61293514868

A novel report on conjugation of Rabbit Anti Porphyromonas gingivalis and carbon quantum dots (CQD@A) synthesized from chlorophyll and its used as a Metronidazole (M) carrier, is presented in this work. Porphyromonas gingivalis is a Gram-negative oral anaerobe which causes inflammation that may lead to tooth loss. In this study, we investigated the bacteria elimination within the cell cytoplasm and identified the penetration, localization, and co-localization of CQD@A conjugated MA (CQD@A-M) with the use of confocal microscopy.

Presenting author biography

SARA MADADI ARDEKANI graduated from UTM university in 2013. She is now a Ph.D. student at the University of Sydney, School of Chemical and Biomolecular Engineering. Her passion is bringing a new idea to connect nanoworld to the healing of deadly disease under the supervision of ASSOCIATE PROFESSOR VINCENT GOMES; she is working on Synthesis of carbon nanomaterials for drug delivery.