Zhi Ping (Gordon) Xu, Li Li, Bei Li


Australian Institute for Bioengineering and Nanotechnology
The University of Queensland, Brisbane, QLD 4072, Australia
Email: gordonxu@uq.edu.au


Layered double hydroxides (LDHs), also known as anionic clay, find a high potential as the drug/gene delivery vehicle. In this talk, I will first report our findings that LDH nanoparticles can be used to effectively co-deliver siRNA and anti-cancer drugs for synergistic therapeutic efficacy.[1,2] We design to load anticancer drug 5-FU with the LDH interlayer and then siRNA on the LDH surface. LDH nanoparticle can efficiently co-deliver anticancer drug 5-FU and siRNA into cancer cells and show the significant inhibition of the cell growth compared to the treatment with either anticancer drug or siRNA, showing the synergy of two therapeutics co-delivered in vitro.

We have recently developed Mn-doped LDH (Mn-LDH) nanoparticles as an efficient magnetic resonance imaging (MRI) contrast agent (CA) for cancer diagnosis.[3] This Mn-LDH MRI CA ultrasensitively responds to the very weakly acidic environment (pH 6.5~7.0, i.e. pH range in tumor microenvironment) with satisfactory imaging performance. Very interestingly, Mn-LDH nanoparticles show clear MR imaging for tumor tissues in mice for three days post intravenous injection. This outstanding performance in T1-weighted MRI might result from the unique microstructure of Mn ions in Mn-LDH framework.

Collectively our findings have demonstrated that LDH nanoparticles are potential theranostic platforms for effective diagnosis and treatment of cancers in vitro and in vivo.



[1] Z.P. Xu et al. J. Am. Chem. Soc. 2006, 128, 36-37.

[2] L. Li, W. Gu, J. Chen, W. Chen, Z. P. Xu, Biomaterials, 2014, 35, 3331-3339.

[3] B. Li, Z. Gu, N. Kurniawan, W. Chen, Z. P. Xu, Adv. Mater. 2017, DOI: 10.1002/adma.201700373.



AEB 313