Naisarg Pujara1,2, Siddharth Jambhrunkar1,2, Kuan Yau Wong2, Michael McGuckin2, Amirali Popat*1,2

 

1The School of Pharmacy, The University of Queensland, Brisbane, QLD 4072, Australia;
2
Inflammatory Disease Biology and Therapeutics Group, Mater Research Institute – The University of Queensland, Translational Research Institute, 37 Kent St, Woolloongabba, QLD 4102, Australia

 

This research work will highlight the potential of soy protein isolate (SPI) to enhance the solubility and rapid dissolution of hydrophobic drugs like resveratrol. Resveratrol (RES) has multiple therapeutic effects including antioxidant, cardioprotective, anti-inflammatory and anticancer activity, however these are limited by the drugs poor aqueous solubility and stability. One good candidate for drug solubility enhancement is SPI derived from soybeans and is used in the food industry due to its functional properties, non-toxic nature, low cost, easy availability and high nutritional values. Here, we report a simple rotavap method for nanoencapsulation of resveratrol into naturally occurring SPI. This would enhance its physicochemical properties including solubility and in-vitro dissolution, which will in turn improve its biological performance. Nano-encapsulated resveratrol was found to be in amorphous form and showed more than two times higher solubility with significantly rapid dissolution as compared to free resveratrol.1 This nanoencapsulation of resveratrol into SPI will boost the clinical effectiveness of RES and could be utilised for other poorly soluble hydrophobic drugs.

Figure 1: (A) Saturated solubility studies of resveratrol (RES) and resveratrol encapsulated SPI nanocomplex (SPI-RES). Statistics: mean ± SD (n=3), t-test; ****p < 0.0001. (B) In-vitro release profile of pure resveratrol (RES) and resveratrol encapsulated SPI nanocomplex (SPI-RES). Statistics: mean ± SD (n=3).

 

1 Pujara, N. Journal of Colloid and Interface Science 2017, 488, 303–308. Enhanced colloidal stability, solubility and rapid dissolution of resveratrol by nanocomplexation with soy protein isolate.

 

Biographic Details

Name: Naisarg Pujara

Title: Mr.

Affiliation, Country: The University of Queensland, Australia

Phone: +61 469569142 E-mail: n.pujara@uq.edu.au

Research interests: Nanotechnology, nanomedicine, nanoparticles

Venue

Room: 
AEB 313