Bei Lia, Zi Gub,* Nyoman Kurniawanc, Weiyu Chena and Zhi Ping Xua,*

 

a Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD 4072, Australia; b School of Chemical Engineering, The University of New South Wales, Sydney, NSW 2052, Australia; c Centre for Advanced Imaging, The University of Queensland, Brisbane, QLD 4072, Australia

 

Recently, Mn(II)-containing nanoparticles1 are explored widely as an attractive alternative to Gd(III)-based T1-weighted magnetic resonance imaging (MRI) contrast agents (CAs)2 for cancer diagnosis. However, to our best knowledge, no Mn-based MRI CAs have been reported to sensitively respond to the very weakly acidic environment (pH 6.5~7.0, i.e. pH range in tumor microenvironment) with satisfactory imaging performance. This talk will present our recent work on devising a novel Mn-based layered double hydroxide (Mn-LDH) nanoparticles with outstanding T1-MRI performance ultrasensitive to the very weak acidity (pH 6.5~7.0), and show clear MR imaging of tumor tissues in mice for at least two days (Figure 1). Thus, together with demonstrated capacity for drug and gene delivery,3 this novel Mn-LDH nanoparticle with ultrasensitive pH response, high relaxivity, and prolonged imaging time, are very potential theranostic agents for cancer treatment.

Figure 1: Schematic illustration of structure related multifunctional properties of Mn-LDH nanoparticles

References

1 Y. Chen, D. L. Ye, M. Y. Wu, H. R. Chen, L. L. Zhang, J. L. Shi, L. Z. Wang, Adv. Mater. 2014, 26, 7019.

2 P. Caravan, J. J. Ellison, T. J. McMurry, R. B. Lauffer, Chem. Rev. 1999, 99, 2293.

3 a) N. Mitter, E. A. Worrall, K. E. Robinson, P. Li, R. G. Jain, C. Taochy, S. J. Fletcher, B. J. Carroll, G. Q. Lu, Z. P. Xu, Nature Plants 2017, 3, 16207; b) D. H. Park, J. Cho, O. J. Kwon, C. O. Yun, J. H. Choy, Angew. Chem. Int. Ed. 2016, 55, 4582.

 

Biographic Details

Name: Bei Li   

Title: PhD candidate

Affiliation, Country: Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, QLD, 4072, Australia

Phone: +61(0)424950833    E-mail: b.li5@uq.edu.au

Research interests: Modification of LDH NPs for in vivo gene/drug delivery and imaging

Venue

Room: 
AEB 313