Martina H Stenzel*, Sylvia Ganda, Sandy Wong, Jiacheng Zhao

 

Centre for Advanced Macromolecular Design (CAMD)
School of Chemistry
University of New South Wales
Sydney, NSW, Australia

 

Material scientists have long turned to nature for inspiration. Many self-assembled systems such as cells are the result of millions of years of evolution and have been optimized over the course. Scientists have aimed at creating similar structures using self-assembled amphiphilic structures such as polymers. Self-assembly of amphiphilic block copolymers in selective solvents is a well-known process and the parameters determining the resulting structures have been studied in detail. Most commonly, micelles are obtained, but also the formation of cylindrical micelles and vesicles is possible. Self-assembly in the presence of additional forces such as crystallization, stacking forces, an additional polymers block or self-assembly in an emulsion system can lead to superimposed structures that lead to nanoobjects beyond traditional micelles.

In this presentation, we will discuss how additional forces can create new nanoparticles that may be suitable for therapeutic purposes. Motivation is to create nanoparticles that can have resemblance of virus-like structures, which are often non-spherical and carry patterned surfaces with bioactive groups.

 
Figure 1: Representative TEM images of PManA70-b-PBA369-b-PVP370 glyco-nanoparticles obtained at various pH values (A: pH4; B: pH 7; C and D: pH 9).

Biographic Details

Name: Martina Stenzel

Title: Scietia Professor

Affiliation, Country: UNSW Sydney, Australia

Phone: +61-2-93854656 E-mail: M.Stenzel@unsw.edu.au

Research interests: Synthesis of nanoparticles, Polymer-drug interaction, behaviour of nanoparticles in spheroid cancer models