Changkui Fu, Shauna Herbst, Cheng Zhang, Andrew K. Whittaker*

 

Australian Institute for Bioengineering and Nanotechnology
The University of Queensland, Brisbane Qld 4072, Australia
ARC Centre of Excellence in Convergent Bio-Nano Science and Technology
The University of Queensland, Brisbane Qld 4072, Australia

 

Magnetic resonance imaging (MRI) has become an essential technique in modern medical diagnosis, providing high-quality anatomic images of the soft tissue in both the healthy and diseased state without the use of harmful radioactive nuclides or ionizing radiation. Specifically, 19F MRI has recently drawn great attention due to its superior advantages such as negligible background interference and capability for accurate and efficient quantification. Conventional 19F MRI agents provide contrast which is largely insensitive to the local tissue environment, resulting in limited biological applications. In this regard, stimuli-responsive 19F MRI agents, that are able to maximise the signal of the target with enhanced signal contrast in response to specific biological stimuli (for example, temperature, pH, metal ions, the presence of enzymes or redox potential), are particularly attractive. This presentation will highlight recently developed polymeric 19F MRI agents that can respond to biological stimuli such as the presence of reactive oxygen species (ROS).

 

Biographic Details

Name Changkui Fu

Title: Dr

Affiliation, Country: AIBN, The University of Queensland, Australia

Phone: +61 334 63864 E-mail: changkui.fu@uq.edu.au

Research interests: polymer synthesis, imaging agent, drug delivery, hydrogel