Hao Song, Yusilawati Ahmad Nor, Meihua Yu, Yannan Yang, Jun Zhang, Hongwei Zhang, Chun Xu, Chengzhong Yu*

 

Australian Institute for Bioengineering and Nanotechnology, The University of Queensland
Brisbane 4072, Australia

 

Nature creations with spiky topological features typically exhibit intriguing surface properties.1 From micrometer-sized pollen grains that can easily stick to hairy insects for pollination to nanoscale virus particles that are highly infectious towards host cells, multivalent interactions are formed taking advantages of rough surfaces.2 Herein, this nature-inspired concept is employed to develop novel drug delivery nano-carriers for biomedical applications.3 A facile new approach is developed to fabricate silica nano-pollens (mesoporous silica nanospheres with rough surfaces), which show enhanced adhesion towards bacteria surface comparing to their counterparts with smooth surfaces. Lysozyme, a natural antimicrobial enzyme, is loaded into silica nano-pollens, showing sustained release behavior, potent antimicrobial activity and long-term total bacterial inhibition up to 3 days towards Escherichia coli. The potent antibacterial activity of lysozyme loaded silica nano-pollens is further demonstrated ex vivo by using a small intestine infection model. Our strategy provides a novel pathway in the rational design of nano-carriers for efficient drug delivery.

Figure 1: Schematic illustration of efficient lysozyme delivery of silica nano-pollens which are adhesive towards bacterial surface.

 

 

1 Wegst, U.G.K. et al. Nat Mater 2015, 14, 23-36. Bioinspired structural materials.

2 Fasting, C. et al. Angew Chem Int Ed 2012, 51, 10472-10498. Multivalency as a Chemical Organization and Action Principle.

3 Song, H. et al. J Am Chem Soc 2016, 138, 6455-6462. Silica nanopollens enhance adhesion for long-term bacterial inhibition.

 

Biographic Details

Name: Hao Song

Title: PhD student

Affiliation/Country: Australian Institute for Bioengineering and Nanotechnology, the University of Queensland, Australia

Phone: +61-7-3346-3804 E-mail: h.song6@uq.edu.au

Research interests: novel porous naomaterials for biomedicial applications, electron tomography analysis of nanomaterials with intricate structures.

Venue

Room: 
AEB 301