Bingyang Shi*,1,2 Dayong Jin,2 Nicolle Packer,2 Roger Chung,1 Shizhang Qiao3


Department of Biomedical Sciences, Faculty of Medicine & Health Sciences, Macquarie University, Sydney, NSW, Australia
ARC Centre of Excellence for Nanoscale BioPhotonics (CNBP), Macquarie University, Sydney, New South Wales, 2109, Australia
Chemical Engineering, the University of Adelaide, South Australia, 5005, Australia
Email: bingyang.shi

Nanoparticles (NPs) are promising platform for theranostics applications such as bioimaging, diagnostics, drug delivery, gene delivery and biosensors. NPs can be designed and developed based on a variety of core materials (metal, semiconductor, silica and organic polymers).

During last five years, we have designed and developed various advanced nanoparticles including polymers based nanoparticles,  1-3 nanogels based nanoparticles,4 dentrimer-like silica nanoparticles,5 gold-silica hybrid nanoparticles, mesoporous silica nanoparticles and upconvertion nanoparticles. Those developed nanoparticles have been applied in drug delivery, gene delivery, early stage cancer detection and photodynamic therapy, the promising results evidence that they will have potential applications in the future medicine.


  1. Shi, B. Y., Shen, Z. Y., Zhang, H., Bi, J. X. & Dai, S. Exploring N-Imidazolyl-O-Carboxymethyl Chitosan for High Performance Gene Delivery. Biomacromolecules 13, 146-153 (2012).
  2. Shi, B. Y. et al. Intracellular Microenvironment Responsive Polymers: A Multiple- stage Transport Platform for High- Performance Gene Delivery. Small 10, 871-877 (2014).
  3. Shi, B. Y., Zhang, H., Shen, Z. Y., Bi, J. X. & Dai, S. Developing a chitosan supported imidazole Schiff-base for high-efficiency gene delivery. Polym Chem-Uk 4, 840-850 (2013).
  4.  B Shi, H Zhang, Qiao, S. Z., J Bi & Dai, S. Intracellular Microenvironment Responsive Label-free Autofluorescent Nanogels for Traceable Gene Delivery Advanced Healthcare Materials In press (2014).
  5. Du, X. et al. Developing Functionalized Dendrimer-Like Silica Nanoparticles with Hierarchical Pores as Advanced Delivery Nanocarriers. Adv Mater 25, 5981-5985 (2013).

Biographic details:

Dr. Shi is a NHMRC-ARC Dementia fellow and Team leader of nanomedicine from Department of Biomedical Sciences, Faculty of Medicine & Health Sciences, Macquarie University, Sydney, NSW, Australia. Phone: + 61 02 98502702; Fax: + 61 02 98502702

Research Interests: 1. Blood brain barrier cross for brain disease therapy; 2. Early stage diseases diagnosis; 3. Bio-Nano interfaces.


AEB 301