Yin. Xiao2*, Zetao. Chen1,2, Krasimir. Vasilev 3,4


1. Institute of Health and Biomedical Innovation & the Australia-China Centre for Tissue Engineering and Regenerative Medicine, Queensland University of Technology, Brisbane 4059, Australia
2. Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University and Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510055, Guangdong, People’s Republic of China
3. Future Industries Institute, University of South Australia, South Australia 5095, Australia
4. School of Engineering, University of South Australia, South Australia 5095, Australia


Osteoimmunomodulation has informed the importance of modulating a favourable osteo-immune environment for osteoblastic lineage differentiation. Nanotopography which was introduced into the development of bone biomaterials is regarded as highly valuable strategy for the development of advanced bone materials. The positive effects of nanotopography on regulating immune response make it possible to utilise the immunomodulatory properties of nanotopography to manipulate the osteo-immune environment. Therefore, the aim of this study was to advance the applications of nanotopography from the view of their osteoimmunomodulatory properties, aiming to shed further light in this field. We found that via tuning the surface chemistry (amine or acrylic acid) and scale of nanotopography (16, 38 and 68 nm), the osteo-immune environment was significantly modulated, including changes in the expression of inflammatory cytokines, osteoclastic activities, osteogenic, angiogenic, and fibrogenic factors. The generated osteo-immune environment significantly affected the osteogenic differentiation of bone marrow stromal cells, with carboxylacid tailored 68 nm surface nanotopography offering the most promising outcome. This study demonstrated that the osteoimmunomodulation could be manipulated via tuning chemistry and nanotopography, which could offer a novel strategy for the applications of nanotopography for the development of advanced bone biomaterials with favourable osteoimmunomodulatory properties .


Biographical sketch

Name:             Yin Xiao, Prof. Dr

Title:               Professor

Affiliation:     Institute of Health and Biomedical Innovation

Organization: Queensland University of Technology 60 Musk Avenue, Kelvin Grove, QLD4034, Australia

Email: yin.xiao@qut.edu.au

Tel:+61 07 31386240

Fax: +61 07 31386030