Mohammad Soheilmoghaddam1, Justin Cooper-White1,2,3,*

 

1 Tissue Engineering and Microfluidics Laboratory, Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD 4072, Australia
2 School of Chemical Engineering, The University of Queensland, Australia 4072
3 Biomedical Manufacturing, Manufacturing Flagship, CSIRO, Clayton, Victoria, Australia,
*(J.J.C.-W.) Tel: +61 3346 3858. E-mail: 
j.cooperwhite@uq.edu.au.

 

Assembling biological and structural scaffold that mimic the well-designed architecture of the native bone has become an essential element in bone tissue-engineering. Modular tissue engineering approach for fabricating an ideal extracellular matrix (ECM) with favorable architecture to achieve successful bone integration and regeneration were developed. Here we bottom-up assembled a series of aligned (PLGA) bioactive electrospun fibers reinforced with rod-shape nano-hydroxyapatite (n-HA) to construct osteon-like structures. These aligned nano fibers modified with highly oriented n-HA showed a significant improvement in mechanical properties. Furthermore, the bone-bonding ability of electrospun scaffolds using simulated body fluid (SBF) solution, revealed a substantial enhancement of bonelike apatites of the PLGA/nHA composites. The osteogenic differentiation of human mesenchymal stem cells (hMSCs) was confirmed significantly higher alkaline phosphate activity as well as calcium mineralization of the nanocomposites compared to pure PLGA fibers while the cells orientation followed the underlying nanofiber morphology.  Our study demonstrated that tailored aligned nanofibers with favorable mechanical properties in the presence of osteo-conductive n-HA could be a promising candidate for engineering bone tissue.

 

Biographic Details

Name : Mohammad Soheilmoghaddam

Title: PhD Candidate

Affiliation, Country: Tissue Engineering and Microfluidics Laboratory, Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD 4072, Australia

Phone: +61 444681231 E-mail: Mohammad.Soheilmoghaddam@uq.net.au

Research interests: : Nanocomposites, Biomicrofluidics, Stem Cells, Stem Cells and Tissue Engineering

 

Name : Justin Cooper-White

Title: Professor

Affiliation, Country: Tissue Engineering and Microfluidics Laboratory, Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD 4072, Australia

Phone: +61 7 334 63858 E-mail: j.cooperwhite@uq.edu.au.

Research interests: Soft Materials, Biomicrofluidics, Stem Cells, Stem Cells and Tissue Engineering