Guangjun Nie*

National Center for Nanoscience and Technology, China
Beijing, 100190 China


In spite of the promising therapeutic potential exhibited by the numerous antitumor nanomedicines, it remains a major challenge for particulate-based therapeutics to effectively transport into solid tumors, especially in stromal enriched tumors. The recent progress on understanding the critical roles and the underlying mechanisms of tumor microenvironment on tumor rapid growth and metastasis has made targeting the tumor microenvironment becomes a feasible strategy to improve the effectiveness of nanomaterials-based cancer diagnosis and therapy. Expression of stromal fibroblasts-specific enzymes and pathological changes of tumor vasculature are the most remarkable hallmarks of tumor microenvironment in almost all types of tumors and can be considered as good specific triggers or targets for design of broad-spectrum and local-environment responsive functional nanomaterial-based platform. Here we report novel biomimetic nanostructures based on oligopeptide self-assemblies that could quickly response and regulate the key components of tumor microenvironment. With such a strategy, the optimal formulations were developed, showing the high activation efficacy and antitumor efficacy. The tailor-made self-assembled biomolecule nanomaterials have the potential to be used in early and late stages of solid tumors, especially for stromal enriched solid tumors, which is expected to be of crucial importance for clinical tumor therapeutics. Although additional research is urgent needed to develop robust methods for targeting and regulating nanomaterials to tumor sites and the supporting environment, the applications of tumor microenvironment-based nanotechnology for safer and more effective antitumor nanomedicine have so far been proven to be successful and will eventually revolutionize the current landscape of cancer therapy [1-7].



[1] Suping Li, Yinlong Zhang, et al. Guangjun Nie. Nanoparticle-mediated local depletion of tumour-associated platelets disrupts vascular barriers and augments drug accumulation in tumours, Nature Biomedical Engineering, DOI: 10.1038/s41551-017-0115-8 (2017)

[2] Yinlong Zhang, Jingyan Wei et al. Guangjun Nie. Inhibition of platelet function using liposomal nanoparticles blocks tumor metastasis, Theranostics (2017)

[3] Tianjiao Ji, et al. Guangjun Nie. An MMP-2 Responsive Liposome Integrating Antifibrosis and Chemotherapeutic Drugs for Enhanced Drug Perfusion and Efficacy in Pancreatic Cancer. ACS AMI (2016)

[4] Tianjiao Ji, Ying Zhao, et al, Transformable Peptide Nanocarriers for Expeditious Drug Release and Effective Cancer Therapy via Cancer-Associated Fibroblast Activation, Angew Chem Int Ed (2016)

[5] Yanping Ding, et al, Guangun Nie. Improvement of stability and efficacy of C16Y therapeutic peptide via molecular self-assembly into tumor-responsive nanoformulation, Molecular Cancer Therapeutics (2015)

[6] Tianjiao Ji, Yanping Ding, et al, Guangjun Nie. Peptide Assemblies Integration of Fibroblast Targeting and Cell Penetration Features for Enhanced Antitumor Drugs Delivery, Advanced Materials (2015)

[7] Ying Zhao, Tianjiao Ji, et al, Guangjun Nie. Self-assembled Peptide Nanoparticles as Tumor Microenvironment Activatable Probes for Tumor Imaging, J Controlled Release (2014)