Hao-Fei Wang, David Wibowo, Zheng-Zhong Shao‡, Anton P.J. Middelberg†, and Chun-Xia Zhao†*


†Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, Queensland, Australia.
‡State Key Laboratory of Molecular Engineering of Polymers, Laboratory of Advanced Materials and Department of Macromolecular Science, Fudan University
 Shanghai, China


Designed peptide surfactants have attracted significant interest due to their superior properties, such as biocompatibility, tailorability of the chemical and physical properties through peptide design, and their self-assembling nature. Their biocompatibility and degradability make them highly advantageous over conventional chemical surfactants, particularly in food and pharmaceutical applications. In this work, two new peptide surfactants (AM-S and C8-AM) were designed based on an amphiphilic peptide surfactant (AM1) by modulating the AM1 sequence with an additional hydrophobic moiety to better understand the links between structure, interfacial activity and emulsification. Both AM-S and C8-AM peptides showed excellent surface activities. Their rapid adsorption kinetics allowed the formation of nanoemulsions with small droplet sizes and narrow size distribution. Both peptide surfactants were observed to effectively stabilize nanoemulsions for weeks. Additionally, the stability of nanoemulsions can be actively reversed by adding a chelating agent. The modular design of AM-S and C8-AM represents a new strategy in tuning the surface activity of peptide surfactants, offering useful information and insights into future designs of peptide surfactants.

Biographic Details

Name: Haofei Wang

Title: Ms

Affiliation, Country: UQ AIBN, Australia

Phone: +61 0431867961   E-mail: haofei.wang@uq.net.au

Research interests: Nanomedicine