Bernd H. A. Rehm


Centre for Cell Factories and Biopolymers (CCFB),
Griffith Institute for Drug Discovery (GRIDD),
Griffith University, Don Young Road, Nathan, QLD, Australia


Bacterial cells are capable to produce various intracellular inclusions1. Our current research focuses on unravelling the molecular mechanisms of the formation of protein-coated polyester inclusions, self-assembling proteins and the exopolysaccharide, alginate. Recent insights into self-assembly pathways of polyester and protein inclusions have enabled bioengineering approaches to produce functional shell-core nano-/micro-structures. A platform technology was developed and offers a vast design space for scalable production of functional nano-/micro-materials efficiently displaying protein-based functions such as e.g. binding domains, fluorescent proteins, antigens and enzymes2. These hierarchical biomolecular assemblies exhibit unique properties. Overall, synthetic biology/bioengineering approaches enabled the design and production of functional materials for a range of medical and industrial uses2,3.


  1. Rehm, B.H.A. (2010) Nature Rev. Microbiol. 8:578-592.

2     Parlane et al., (2016) ACS Biomaterial Science and Engineering, DOI: 10.1021/acsbiomaterials.6b00355.

3     Rehm, B.H.A. (2017) Current Opinion in Biotechnology, 48, 42-53