Mohammad Kalantari, Chengzhong Yu*


Australian Institute for Bioengineering and Nanotechnology
The University of Queensland
Brisbane, QLD, Australia


Rationally designed nanocarrier with custom-made properties is of great importance in cutting-edge nanobiocatalysis.1 Immobilized lipase-based catalytic processes have great potential in pharmaceutical industry, fuel production and food processing. However, their practical application is severely hampered due to their low catalytic performance. In this work, we report the synthesis of two families of dendritic mesoporous organosilica nanoparticles (DMONs) with purpose-designed hydrophobic moieties: on the pore surface and inside the framework. The sample possessing the highest organic content on the surface exhibits a specific activity 5.2 times higher than that of the free enzyme, better than the best performances reported to date.2 It is further demonstrated that increasing hydrophobicity through incorporation of high organic content inside the framework increases the specific activity to 6.5 times higher compared to free lipase. Comparison with nonporous silica nanoparticles reveals that the unique dendritic structure is critical to increase the stability of immobilized lipase. Our findings may find promising applications in biomedicine, biosensor and biofuel conversion.

1 Bornscheuer, U. T. Nature 2012, 485, 185-194. Engineering the thirdwave of biocatalysis.

2 Zhou, Z. Advanced Materials 2011, 23, 2627-2632. Mesoporous Organosilicas With Large Cage-Like Pores for High Efficiency Immobilization of Enzymes.



Biographic Details

Mohammad Kalantari

Title: Mr.

Affiliation, Country: Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Australia

Phone: +491153882 E-mail:

Research interests: Nanobiocatalysis, Organosilica nanoparticles


AEB 301