Huan Wang, Yuanjin Zhao*


State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University

Nanjing, Jiangsu, China


Enzymes are powerful biocatalysts for a broad variety of chemical reactions in lives, and many kind of them are working in cascade. To enlarge the enzymes into broad applications, enzymatic carriers have been developed and used for industrial field. However, many kinds of enzymatic carriers only provide limited surface area for the enzymes immobilization. In addition, because of the indistinguishability of the enzymatic carriers, the investigation of the multienzymes biocatalysis systems is lacking. Herein, we present the inverse opal hydrogel particles as enzymatic carriers (Figure 1a). These particles were negatively replicated from spherical silica colloidal crystal beads and were endowed with ordered penetrating structure and vivid structural colors. The penetrating structure could provide a high specific surface area, which contributed to catalysis efficiency improvement, and the vivid colors could be used for the encoding of different kind of enzymes2. When the particles immobilized with enzymes that catalyse substrate in cascade were capsuled in together, the bio-inspired cascade reaction system could be constructed (Figure 1b). These features of the inverse opal hydrogel particles indicate that they are ideal enzymatic carriers for biocatalysis.


1 DiCosimo R, McAuliffe J, Poulose A J, Bohlmann G. Chem. Soc. Rev. 2013, 42, 6437-6474. Industrial use of immobilized enzymes.

2 Wang H, Gu H C, Chen Z Y, Shang L R, Zhao Z, Gu Z Z, Zhao Y J. ACS Appl. Mater. Interfaces 2017, 9, 12914-12918. Enzymatic Inverse Opal Hydrogel Particles for Biocatalyst.  


Biographic Details

Huan Wang

Title: Mr.

Affiliation, Country: Southeast University, China

Phone: +86 15298369792 E-mail:

Research interests: Photonic crystal, Hydrogel,  Biomimics