Faheem Amir, Zhongfan Jia, and Michael J. Monteiro*


Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, Queensland 4072, Australia


Building complex polymer architectures has been driven by the quest to obtain new and predictable solution and bulk properties. Incorporating sequence control into these architectures through the judicious choice of monomer or macromers will have the potential to create advanced polymer materials1-3. The iterative growth approach through either iterative sequential addition (ISG)4 or iterative exponential growth (IEG)5 of monomer provides precise control over the monomer sequence, chain length and in some cases stereocontrol. A general strategy through the use of direct azidation of alcohols allowed the sequence control of macromers via both the iterative sequential growth and iterative exponential growth methods. The chemistry was highly efficient in building polymers from a sequence of compositionally different macromers tethered together in close proximity. Using the DPPA/DBU method for near quantitative azidation of the benzyl alcohol moiety, sequence controlled polymers were made via a direct and one-step procedure for CuAAC activation. With four different macromers, spherical miktoarm star-like polymers of 50 000 molecular weight were prepared with a low dispersity, and the polymer coil size depended on the type of added macromer. Polymers made via the iterative methods opens the way for the design of advanced materials with predictable properties.


  1. Lutz, J.-F.; Lehn, J.-M.; Meijer, E. W.; Matyjaszewski, K., Nat. Rev. Mater. 2016, 1, 16024.
  2. Lutz, J.-F.; Ouchi, M.; Liu, D. R.; Sawamoto, M., Science 2013, 341 (6146).
  3. Whittaker, M. R.; Urbani, C. N.; Monteiro, M. J., Am. Chem. Soc. 2006 128 (35), 11360-11361
  4. Merrifield, R. B., J. Am. Chem. Soc. 1963, 85 (14), 2149-2154.
  5. Barnes, J. C.; Ehrlich, D. J. C.; Gao, A. X.; Leibfarth, F. A.; Jiang, Y.; Zhou, E.; Jamison, T. F.; Johnson, J. A., Nat. Chem. 2015, 7 (10), 810-815.


Faheem Amir Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Australia Phone: 073364160 Fax: 0733463973 E-mail: faheem.solangi@uqconnect.edu.au

Personal History2017-current, Postdoctoral Research Fellow (Monteiro Group) AIBN, The University of Queensland, Australia.

Research interest: Living radical polymerization, ‘click’ reactions, organic synthesis and synthesis of complex polymeric architectures.