Thejus Baby, Anton P.J. Middelberg, Chun-Xia Zhao*,

 

Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, St Lucia, QLD 4072, Australia

 

Microfluidics allows handling of liquids at the nanoliter scale and proves to be superior over conventional bulk methods of synthesis. The ability of microfluidic systems to rapidly mix reagents to provide homogeneous reaction environments, to vary the reaction conditions continuously, and to even allow reagent addition during the progress of a reaction, are some of the key features that makes them attractive for nanoparticle synthesis1. However, applications of this technology for making nanoparticles for drug delivery is usually limited owing to its low production rates2. Several fabrication approaches have been developed to achieve high yields but often involve the use of intricate devices through complex fabrication procedures. Herein, we investigated the throughput capacities of hydrodynamic flow-focusing microfluidic devices for the production of poly (lactide-co-glycolide)-b-polyethylene glycol (PLGA-PEG) nanoparticles. The effects of different features of microfluidic design, such as channel width, channel depth, channel structure and flow rate ratios, on particle size, size distribution, and production rates were studied. In comparison to the frequently used hydrodynamic flow-focusing microfluidic device, which has a production rate of 1.8 mg/h, our simple approach was capable of increasing the production rates by more than two orders of magnitude up to 288 mg/h. This study demonstrated the utilization of facile 2D microfluidic devices for large-scale production of polymeric nanoparticles and could eliminate the need for the fabrication of complex designs.

References:

1  Karnik, R. Nano Lett. 2008, 8, 2906 - 2912. Microfluidic platform for controlled synthesis of polymeric    nanoparticles.

2 Lim, J.M. Nanomedicine. 2014, 3, 20 - 31. Parallel microfluidic synthesis of size-tunable polymeric nanoparticles using 3D flow focusing towards in vivo study.

 

Biographic Details

Name : Thejus Baby                                                                                                    

Title: Ms.

Affiliation, Country: AIBN, UQ, Australia

Phone: 0423494112,  E-mail: t.baby@uq.edu.au

Research interests: Nanomedicine, Drug Delivery, Polymers, Microfluidics