Angus P.R. Johnston,1,2* Laura I. Selby,1 Georgina K. Such3

 

1 Drug Delivery, Disposition and Dynamics,
Monash Institute of Pharmaceutical Sciences, Monash University, 399 Royal Parade, Parkville, Melbourne, Australia, 3052
2 ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, Melbourne, Australia, 3052
3Department of Chemistry, The University of Melbourne, Parkville, Victoria, 3010

 

Targeted delivery of drugs to specific cells in the body has the potential to significantly improve the treatment of many diseases. However, to engineer ‘smart’, responsive materials for drug delivery it is also essential to understand how nanoparticles interact with cells. 

We have developed hybrid protein/polymer materials that spontaneously self-assemble into nanoparticles that can be targeted to specific cells. ,2 To understand how these particles interact with biological systems we have developed molecular sensors that can quantify the internalisation, processing and trafficking of nanoparticles in cells.3 This presentation will focus on understanding the targeting of protein/polymer nanoparticles to cells, and their subsequent internalisation once they have bound to the cell.4 It will also outline the progress we are making towards understanding the fate of the nanoparticles once they have been internalised into the cell.

[1] Wong, A. S. M. et. al. Soft Matter. Soft Matter 2015, 11, 2993–3002.

2 Mann, S. K. et. al. Polym. Chem. 2016, 7, 6015–6024.

3 Liu, H. et. al. Angew Chem Int Edit 2013, 52, 5744–5748.

4 Mann, S. K. et. al. Pharmaceut Res 2016, 33, 2421–2432.

5 Wong, A. S. M. et. al. ACS Macro Letters 2017, 315–320.

 

Biographic Details

Name: Angus P.R. Johnston

Title: Dr

Affiliation, Country: Australia

Phone: +61 3 9903 9263 E-mail: angus.johnston@monash.edu

Research interests: targeted drug delivery, cellular trafficking, molecular sensors