Yannan Yang, Yao Lu, Chengzhong Yu*


Australian Institute for Bioengineering and Nanotechnology, The University of Queensland
Brisbane, Queensland, Australia


Recent progresses in nanostructured immuno-adjuvants have offered great opportunities in promoting immune responses for prevention or treatment of disease (e.g. cancer). However, challenges exist in developing potent and safe adjuvants for generating robust and long-lasting adaptive immunity. We have recently developed an innovative anion assisted molecular assembly synthetic approach,[1]-2 which allows the construction of the organic-inorganic hybrid silica materials with multi-shelled dendritic architecture. Double-shelled dendritic mesoporous organosilica hollow spheres are an excellent adjuvant and provide superior immunity in cancer immunotherapy, and better than their counterparts either with a pure silica composition or a single-walled architecture. The findings from this study may provide new opportunities for extending the applications of the large family of classical organosilica materials with rationally designed nanostructures for effective cancer immunotherapy.


1 Y. Yang, S. Bernardi, H. Song, J. Zhang, M. Yu, J. C. Reid, E. Strounina, D. J. Searles, and C. Yu, Chem. Mater. 2016, 28, 704−707. Anion Assisted Synthesis of Large Pore Hollow Dendritic Mesoporous Organosilica Nanoparticles: Understanding the Composition Gradient.

2 Y. Yang, J. Wan, Y. Niu, Z. Gu, J. Zhang, M. Yu, and C. Yu,  Chem. Mater. 2016, 28, 9008−9016. Structure-Dependent and Glutathione-Responsive Biodegradable Dendritic Mesoporous Organosilica Nanoparticles for Safe Protein Delivery.

3 Y. Yang, Y. Lu, P. L. Abbaraju, J. Zhang, M. Zhang, G. Xiang, and C. Yu. Angew. Chem. Int. Ed., 2017, DOI: 10.1002/anie.201701550. Multi-shelled Dendritic Mesoporous Organosilica Hollow Spheres: Roles of Composition and Architecture in Cancer Immunotherapy.


Biographic Details

Name: Yannan Yang

Title: Mr.

Affiliation, Country: Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, St Lucia, QLD. Australia.

E-mail: yannan.yang@uqconnect.edu.au

Research interests: hybrid mesoporous materials,  nanomedicine


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